Taiwan has been well recognized for the excellence in healthcare services and biomedical innovations. The practice of “co-creation” model in healthcare can further enhance innovation and outcome value with inputs from various stakeholders. To realize the ideation of unmet needs with Invent, refine, and test cycle of medical products (e.g. device and drug) design and development, ITRI has adopted “open innovation system platform” (OISP) to response to the emerging needs of technical integration. We will highlight co-creation projects and share with you about our learned experiences in the implementation processes of iPMx molecular diagnostic system for SARS-Cov-2, Open Ventilator project, fiber optical coherent tomography system (f-OCT), and Image-Guided Radiofrequency Ablation (iRFA). These efforts align with the technology roadmap of ITRI’s 2030 and BTC 2020 data driven precision health goal for both smart med-tech and health-tech with the integration of ICT enabling technologies. With the support from MOEA DOIT, ITRI has worked with academic/industrial partners to establish a “Taiwan Integrated Biomedical Industrial Center (TIBIC)” to facilitate effective translational research of medical/healthcare products with co-creation mindset for the development of ecosystem.